CAS No.: 135729-62-3
盐酸帕洛诺司琼 Catalog No. CSN13827
Synonyms: RS 25259;RS 25259 197;Palonosetron (hydrochloride)
Palonosetron HCl is a carbazole-derived and selective 5-HT3 receptor antagonist.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01339260 Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse << Phase 3 Completed - - NCT01339260 - - Completed - - NCT00359567 Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse << Phase 3 Completed - Japan ... more >> National Cancer Center 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan, 104-0045 Collapse << - 更多
- 参考文献
- [1] Gralla R, Lichinitser M, et al. Palonosetron improves prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy: results of a double-blind randomized phase III trial comparing single doses of palonosetron with ondansetron. Ann Oncol. 2003 Oct;14(10):1570-7.
- [2] Wong EH, Clark R, et al. The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro. Br J Pharmacol. 1995 Feb;114(4):851-9.
- [3] Hothersall JD, Moffat C, Connolly CN. Prolonged inhibition of 5-HT₃ receptors by palonosetron results from surface receptor inhibition rather than inducing receptor internalization. Br J Pharmacol. 2013 Jul;169(6):1252-62.
- [4] Hu X, Tan F, Gong L. Higher dose of palonosetron versus lower dose of palonosetron plus droperidol to prevent postoperative nausea and vomiting after eye enucleation and orbital hydroxyapatite implant surgery: a randomized, double-blind trial. Drug Des Devel Ther. 2017 May 15;11:1465-1472.
- [5] Celio L, Niger M, Ricchini F, Agustoni F. Palonosetron in the prevention of chemotherapy-induced nausea and vomiting: an evidence-based review of safety, efficacy, and place in therapy. Core Evid. 2015 Aug 21;10:75-87.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 135729-62-3 | 储存条件 |
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| 分子式 | C19H25ClN2O | 运输 | 蓝冰 | |||||
| 分子量 | 332.87 | 别名 | RS 25259;RS 25259 197;Palonosetron (hydrochloride);RS 25233-197;RS25233-198;US brand name: Aloxi;盐酸帕洛诺司琼 | |||||
| 溶解度 |
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动物实验配方 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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| NCT01339260 | Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse << | Phase 3 | Completed | - | - |
| NCT01339260 | - | - | Completed | - | - |
| NCT00359567 | Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse << | Phase 3 | Completed | - | Japan ... more >> National Cancer Center 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan, 104-0045 Collapse << |
| NCT01111942 | Head and Neck Cancer | Early Phase 1 | Terminated(lack of enrollment) | - | United States, Illinois ... more >> Southern Illinois University School of Medicine Springfield, Illinois, United States, 62701 Collapse << |
| NCT00381862 | Colorectal Cancer ... more >> Nausea and Vomiting Collapse << | Phase 2 | Completed | - | United States, Georgia ... more >> St. Josephs/Cander Hospital Savannah, Georgia, United States, 31405 United States, Hawaii Kaiser Permanente Hilo, Hawaii, United States, 86720 United States, Illinois Ingalls Memorial Hospital Harvey, Illinois, United States, 60426 United States, Missouri Kansas City Cancer Center Kansas City, Missouri, United States, 64104 United States, Oregon OHSU Knight Cancer Institute Portland, Oregon, United States, 97239-3098 United States, Texas Texas A & M university / Scott and White Clinic Temple, Texas, United States, 76508 Collapse << |
| NCT02532634 | Cancer Tumors | Phase 4 | Completed | - | Korea, Republic of ... more >> St. Vincent`S Hospital Suwon, Gyeonggi, Korea, Republic of, 16247 Keimyung University Dongsan Medical Center Daegu, Korea, Republic of Chungnam National University Hospita Daejeon, Korea, Republic of Pusan National University Hospital Pusan, Korea, Republic of Kangbuk Samsung Hospital Seoul, Korea, Republic of Kangdong Sacred Heart Hospital Seoul, Korea, Republic of Samsung Medical Center Seoul, Korea, Republic of Seoul St. Mary's Hospital Seoul, Korea, Republic of Severance Hospital Seoul, Korea, Republic of Ajou University Hospital Suwon, Korea, Republic of Collapse << |
| NCT00381862 | - | - | Completed | - | - |
| NCT00600353 | - | - | Completed | - | - |
| NCT00600353 | Myeloma, Plasma-Cell ... more >> Lymphoma, Malignant Collapse << | Phase 2 | Completed | - | United States, Kansas ... more >> University of Kansas Medical Center Kansas City, Kansas, United States, 66160 Collapse << |
| NCT02635828 | Postoperative Nausea and Vomit... more >>ing Collapse << | Phase 4 | Completed | - | - |
| NCT01568268 | Laparoscopic Gynecologic, Abdo... more >>minal, Other Surgery General Anesthesia Collapse << | Phase 3 | Completed | - | Korea, Republic of ... more >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 Bungdang Seoul National University Hospital Seoul, Korea, Republic of Kangpook Samsung Hospital Seoul, Korea, Republic of Sangye Bahk Hospital, Inje School of Medicine Seoul, Korea, Republic of Collapse << |
| NCT01370408 | - | - | Completed | - | - |
| NCT01370408 | Chemotherapy-induced Nausea an... more >>d Vomiting Collapse << | Phase 2 | Completed | - | United States, Georgia ... more >> Northside Hospital Atlanta, Georgia, United States, 30342 Collapse << |
| NCT00661674 | Substance-Related Disorders | Not Applicable | Completed | - | United States, California ... more >> Stanford University School of Medicine Stanford, California, United States, 94305 Collapse << |
| NCT02116530 | Hematopoietic/Lymphoid Cancer ... more >> Nausea and Vomiting Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 3 | Completed | - | - |
| NCT02635828 | - | - | Completed | - | - |
| NCT00661674 | - | - | Completed | - | - |
| NCT01952626 | Morphine Adverse Reaction | Not Applicable | Completed | - | Korea, Republic of ... more >> Kyungpook National Hospital Daegu, Korea, Republic of, 700-721 Collapse << |
| NCT00306735 | Multiple Myeloma | Phase 2 | Completed | - | United States, Indiana ... more >> Indiana Blood and Marrow Transplantation Beech Grove, Indiana, United States, 46107 United States, New York Cornell Medical Center New York, New York, United States, 10021 United States, North Carolina Wake Forest Medical Center Winston-Salem, North Carolina, United States, 27157 United States, Oregon Oregon Health & Science University Portland, Oregon, United States, 97239 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Fox Chase-Temple Philadelphia, Pennsylvania, United States, 19111 United States, Texas Baylor University Blood and Marrow Transplantation Dallas, Texas, United States, 75246 MD Anderson Cancer Center Houston, Texas, United States, 77030 Texas Transplant Institute San Antonio, Texas, United States, 78229 United States, Virginia Fairfax-Northern Virginia Hematology-Oncology PC Fairfax, Virginia, United States, 22031 Collapse << |
| NCT02116530 | - | - | Completed | - | - |
| NCT00475085 | Nausea | Phase 3 | Completed | - | United States, Alabama ... more >> MBCCOP - Gulf Coast Mobile, Alabama, United States, 36695 United States, Illinois CCOP - Central Illinois Decatur, Illinois, United States, 62526 United States, Kansas CCOP - Wichita Wichita, Kansas, United States, 67214-3882 United States, Michigan CCOP - Grand Rapids Grand Rapids, Michigan, United States, 49503 CCOP - Kalamazoo Kalamazoo, Michigan, United States, 49007-3731 United States, Minnesota CCOP - Metro-Minnesota St. Louis Park, Minnesota, United States, 55416 United States, Missouri CCOP - Kansas City Kansas City, Missouri, United States, 64131 United States, Nevada CCOP - Nevada Cancer Research Foundation Las Vegas, Nevada, United States, 89106 United States, New York CCOP - Hematology-Oncology Associates of Central New York East Syracuse, New York, United States, 13057 CCOP - North Shore University Hospital Manhassett, New York, United States, 11030 United States, North Carolina CCOP - Southeast Cancer Control Consortium Goldsboro, North Carolina, United States, 27534-9479 United States, Ohio CCOP - Columbus Columbus, Ohio, United States, 43215 CCOP - Dayton Dayton, Ohio, United States, 45429 United States, South Carolina CCOP - Greenville Greenville, South Carolina, United States, 29615 United States, Washington CCOP - Northwest Tacoma, Washington, United States, 98405-0986 United States, Wisconsin CCOP - Marshfield Clinic Research Foundation Marshfield, Wisconsin, United States, 54449 Collapse << |
| NCT02970643 | Chemotherapy-induced Nausea an... more >>d Vomiting Collapse << | Not Applicable | Unknown | December 2017 | - |
| NCT03578081 | Malignant Neoplasm | Phase 3 | Recruiting | March 2020 | - |
| NCT00952133 | - | - | Completed | - | - |
| NCT01031498 | - | - | Completed | - | - |
| NCT01031498 | Acute Myelogenous Leukemia ... more >> Chemotherapy-induced Nausea and Vomiting Collapse << | Phase 2 | Completed | - | United States, Texas ... more >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT00410488 | Sarcoma Nause... more >>a Vomiting Collapse << | Not Applicable | Completed | - | United States, Texas ... more >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT00952133 | PONV | Phase 4 | Completed | - | United States, New York ... more >> NYU Langone Medical Center New York, New York, United States, 10016 Collapse << |
| NCT01169805 | Laparoscopic Marsupialization ... more >>of Renal Cyst Collapse << | Not Applicable | Completed | - | Korea, Republic of ... more >> Severance Hospital, Yonsei University College of Medicine Seoul, Korea, Republic of, 120-752 Collapse << |
| NCT00475085 | - | - | Completed | - | - |
| NCT01363479 | Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse << | Phase 3 | Completed | - | - |
| NCT00410488 | - | - | Completed | - | - |
| NCT02557035 | - | - | Completed | - | - |
| NCT02557035 | Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse << | Phase 3 | Completed | - | - |
| NCT01363479 | - | - | Completed | - | - |
| NCT00900757 | Malignant Glioma | Phase 2 | Completed | - | United States, North Carolina ... more >> The Preston Robert Tisch Brain Tumor Center at Duke Durham, North Carolina, United States, 27710 Collapse << |
| NCT00900757 | - | - | Completed | - | - |
| NCT01836705 | Neoplasm Malignant | Phase 1 | Completed | - | United States, California ... more >> Investigational Site Number 840003 Los Angeles, California, United States, 90048 United States, Georgia Investigational Site Number 840007 Augusta, Georgia, United States, 30912 United States, Michigan Investigational Site Number 840002 Detroit, Michigan, United States, 48201 United States, Missouri Investigational Site Number 840001 St Louis, Missouri, United States, 63110 United States, Ohio Investigational Site Number 840004 Cincinnati, Ohio, United States, 45267-0542 United States, Pennsylvania Investigational Site Number 840005 Philadelphia, Pennsylvania, United States, 19111 United States, Texas Investigational Site Number 840006 San Antonio, Texas, United States, 78229 Investigational Site Number 840008 San Antonio, Texas, United States, 78229 Belgium Investigational Site Number 056001 Bruxelles, Belgium, 1200 Investigational Site Number 056002 Gent, Belgium, 9000 Collapse << |
| NCT00967499 | Postoperative Nausea and Vomit... more >>ing Collapse << | Phase 2 | Completed | - | United States, Arizona ... more >> Precision Trials Phoenix, Arizona, United States, 85032 United States, California Accurate Clinical Trials, Inc Laguna Hills, California, United States, 92653 University of California San Francisco San Francisco, California, United States, 94115 United States, Florida University of Miami Miami, Florida, United States, 33136 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Ohio Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Texas Scott and White Hospital Temple, Texas, United States, 76508 Collapse << |
| NCT00553059 | Chemotherapy-induced Nausea an... more >>d Vomiting Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 3 | Completed | - | United States, Missouri ... more >> Cancer Research for the Ozarks Springfield, Missouri, United States, 65807 United States, South Carolina CCOP - Greenville Greenville, South Carolina, United States, 29615 United States, Texas University of Texas M.D. Anderson CCOP Research Base Houston, Texas, United States, 77030-4009 United States, Vermont Vermont Cancer Center at University of Vermont Burlington, Vermont, United States, 05405 Collapse << |
| NCT03649230 | - | - | Recruiting | March 30, 2020 | Canada, Alberta ... more >> Tom Baker Cancer Center Not yet recruiting Calgary, Alberta, Canada Canada, New Brunswick The Moncton Hospital Not yet recruiting Moncton, New Brunswick, Canada Canada, Nova Scotia NSHA-QEII Health Sciences Centre Not yet recruiting Halifax, Nova Scotia, Canada Cape Breton Cancer Centre Recruiting Sydney, Nova Scotia, Canada Canada, Ontario Royal Victoria Regional Health Centre Not yet recruiting Barrie, Ontario, Canada William Osler Health System Not yet recruiting Brampton, Ontario, Canada Grand River Regional Cancer Centre Recruiting Kitchener, Ontario, Canada London Health Sciences Centre Not yet recruiting London, Ontario, Canada Thunder Bay Regional Health Sciences Centre Not yet recruiting Thunder Bay, Ontario, Canada St. Michael's Hospital Not yet recruiting Toronto, Ontario, Canada Sunnybrook Health Sciences Center Not yet recruiting Toronto, Ontario, Canada Windsor Regional Cancer Centre Recruiting Windsor, Ontario, Canada Canada, Quebec Centre Integre de Sante et de Services Sociaux de la Monteregie-Centre Not yet recruiting Greenfield Park, Quebec, Canada Cisss de Chaudiere-Appalaches Not yet recruiting Lévis, Quebec, Canada Segal Cancer Centre-Jewish General Hospital Not yet recruiting Montréal, Quebec, Canada Centre de recherche du CHUS and Hopital Fleurimont Not yet recruiting Sherbrooke, Quebec, Canada Canada, Saskatchewan Saskatoon Cancer Centre Not yet recruiting Saskatoon, Saskatchewan, Canada Collapse << |
| NCT01650961 | Anesthesia, General ... more >> Palonosetron Collapse << | Not Applicable | Completed | - | Korea, Republic of ... more >> Seoul National University Hospital Seoul, Korea, Republic of Collapse << |
| NCT01640340 | Malignant Neoplasm | Not Applicable | Completed | - | United States, Ohio ... more >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 Collapse << |
| NCT02205164 | Chemotherapy Induced Nausea an... more >>d Vomiting Collapse << | Phase 2 | Unknown | October 2014 | Italy ... more >> Università-Azienda Policlinico di Bari Active, not recruiting Bari, BA, Italy, 70124 Ospedale Perrino Recruiting Brindisi, BR, Italy, 72010 Contact: Angela Melpignano, MD brinemat@tin.it Principal Investigator: Angela Melpignano, MD Ospedale Pugliese-Ciacco Active, not recruiting Catanzaro, CZ, Italy, 88100 IRCCS Casa Sollievo della Sofferenza Recruiting San Giovanni Rotondo, FG, Italy, 71013 Contact: Nicola Cascavilla, MD nicola.cascavilla@tin.it Principal Investigator: Nicola Cascavilla, MD Ospedale Vito Fazzi Recruiting Lecce, LE, Italy, 73100 Contact: Nicola Di Renzo, MD direnzo.ematolecce@libero.it Principal Investigator: Nicola Di Renzo, MD Ospedale "Cardinale Panico" Recruiting Tricase, LE, Italy, 73100 Contact: Vincenzo Pavore, MD salentoematologia@piafondazionepanico.it Principal Investigator: Vincenzo Pavone, MD A.O. Riuniti Papardo - Piemonte Recruiting Messina, ME, Italy, 98121 Contact: Donato Mannina, MD donadani@tiscali.it Principal Investigator: Donato Mannina, MD Casa di Cura "La Maddalena" Recruiting Palermo, PA, Italy, 90127 Contact: Maurizio Musso, MD mamusso@libero.it Principal Investigator: Maurizio Musso, MD Ospedale Ascoli Civico Palermo Recruiting Palermo, PA, Italy, 90127 Contact: Anxur Merenda, MD anxurmerenda@libero.it Principal Investigator: Anxur Merenda, MD Ospedale Moscati Recruiting Taranto, TA, Italy, 74100 Contact: Patrizio Mazza, MD ematologia.taranto@libero.it Principal Investigator: Patrizio Mazza, MD ARON " Cardarelli" Recruiting Napoli, Italy, 80121 Contact: Felicetto Ferrara, MD felicettoferrara@katamail.com Principal Investigator: Felicetto Ferrara, MD Collapse << |
| NCT00343863 | Male Breast Cancer ... more >> Nausea and Vomiting Stage I Breast Cancer Stage II Breast Cancer Stage IIIA Breast Cancer Collapse << | Not Applicable | Completed | - | United States, Washington ... more >> Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 Collapse << |
| NCT01640340 | - | - | Completed | - | - |
| NCT00895245 | Nausea and Vomiting ... more >> Stage III Squamous Cell Carcinoma of the Hypopharynx Stage III Squamous Cell Carcinoma of the Larynx Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity Stage III Squamous Cell Carcinoma of the Nasopharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage IV Squamous Cell Carcinoma of the Hypopharynx Stage IV Squamous Cell Carcinoma of the Larynx Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IV Squamous Cell Carcinoma of the Nasopharynx Stage IV Squamous Cell Carcinoma of the Oropharynx Collapse << | Phase 2 | Terminated(Study stopped due t... more >>o lack of efficacy in first 6 patients) Collapse << | - | United States, Washington ... more >> Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 Collapse << |
| NCT03367572 | Breast Carcinoma | Phase 3 | Recruiting | May 1, 2023 | United States, New York ... more >> University of Rochester NCORP Research Base Recruiting Rochester, New York, United States, 14642 Contact: Joseph Roscoe 585-275-5513 joseph_roscoe@urmc.rochester.edu Principal Investigator: Joseph Roscoe Collapse << |
| NCT00343460 | - | - | Completed | - | - |
| NCT00636805 | Brain Cancer | Phase 2 | Terminated(Study was halted ea... more >>rly after 63 subjects were enrolled due to slow accrual.) Collapse << | - | United States, North Carolina ... more >> Duke University Medical Center Durham, North Carolina, United States, 27710 Collapse << |
| NCT00343863 | - | - | Completed | - | - |
| NCT00895245 | - | - | Terminated(Study stopped due t... more >>o lack of efficacy in first 6 patients) Collapse << | - | - |
| NCT00343460 | Nausea and Vomiting ... more >> Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 3 | Completed | - | - |
| NCT00903396 | Anal Cancer C... more >>arcinoma of the Appendix Colorectal Cancer Extrahepatic Bile Duct Cancer Gallbladder Cancer Gastric Cancer Gastrointestinal Carcinoid Tumor Liver Cancer Nausea and Vomiting Pancreatic Cancer Primary Peritoneal Cavity Cancer Small Intestine Cancer Collapse << | Phase 2 | Terminated(Slow accrual) | - | - |
| NCT00636805 | - | - | Terminated(Study was halted ea... more >>rly after 63 subjects were enrolled due to slow accrual.) Collapse << | - | - |
| NCT00903396 | - | - | Terminated(Slow accrual) | - | - |
| NCT03097588 | Hematopoietic Cell Transplanta... more >>tion Recipient Malignant Neoplasm Collapse << | Phase 2 | Recruiting | May 2019 | United States, Oregon ... more >> OHSU Knight Cancer Institute Recruiting Portland, Oregon, United States, 97239 Contact: Joseph Bubalo 503-494-8007 bubaloj@ohsu.edu Principal Investigator: Joseph Bubalo Collapse << |
| NCT01481831 | Neoplasms Che... more >>motherapy-Induced Nausea and Vomiting Collapse << | Phase 4 | Completed | - | China, Anhui ... more >> Anhui Provincial Hospital Hefei, Anhui, China China, Beijing Chinese Academy of Medical Sciences Cancer Hospital Beijing, Beijing, China Chinese PLA 301 Hospital Beijing, Beijing, China Chinese PLA 307 Hospital Beijing, Beijing, China Chinese PLA Navy General Hospital Beijing, Beijing, China China, Fujian Fuzhou General Hospital of Nanjing Military Command Fuzhou, Fujian, China China, Guangxi Guangxi Cancer Hospital Nanning, Guangxi, China China, Hunan The Second Xiangya Hospital of Central South University Changsha, Hunan, China China, Jiangsu The First People's Hospital of Changzhou Changzhou, Jiangsu, China Nanjing General Hospital of Nanjing Military Command Nanjing, Jiangsu, China The First Affiliated Hospital of Soochow University Suzhou, Jiangsu, China The Fourth People's Hospital of Wuxi Wuxi, Jiangsu, China China, Shandong Shandong Cancer Hospital Jinan, Shandong, China Shandong Provincial Hospital Jinan, Shandong, China The Affiliated Hospital of Medical College Qingdao University Qingdao, Shandong, China China, Shanghai Shanghai Changzheng Hospital Shanghai, Shanghai, China Shanghai Xinhua Hospital Shanghai, Shanghai, China China, Shanxi Tangdu Hospital of Fourth Military Medical University Xian, Shanxi, China Collapse << |
| NCT03148704 | - | - | Recruiting | June 8, 2018 | China, Jiangsu ... more >> The 81st Hostital of PLA Recruiting Nanjing, Jiangsu, China, 210000 Contact: qin shukui Collapse << |
| NCT01339260 | Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse << | Phase 3 | Completed | - | - |
| NCT01111942 | Head and Neck Cancer | Early Phase 1 | Terminated(lack of enrollment) | - | United States, Illinois ... more >> Southern Illinois University School of Medicine Springfield, Illinois, United States, 62701 Collapse << |
| NCT00381862 | Colorectal Cancer ... more >> Nausea and Vomiting Collapse << | Phase 2 | Completed | - | United States, Georgia ... more >> St. Josephs/Cander Hospital Savannah, Georgia, United States, 31405 United States, Hawaii Kaiser Permanente Hilo, Hawaii, United States, 86720 United States, Illinois Ingalls Memorial Hospital Harvey, Illinois, United States, 60426 United States, Missouri Kansas City Cancer Center Kansas City, Missouri, United States, 64104 United States, Oregon OHSU Knight Cancer Institute Portland, Oregon, United States, 97239-3098 United States, Texas Texas A & M university / Scott and White Clinic Temple, Texas, United States, 76508 Collapse << |
| NCT01339260 | - | - | Completed | - | - |
| NCT02116530 | - | - | Completed | - | - |
| NCT02532634 | Cancer Tumors | Phase 4 | Completed | - | Korea, Republic of ... more >> St. Vincent`S Hospital Suwon, Gyeonggi, Korea, Republic of, 16247 Keimyung University Dongsan Medical Center Daegu, Korea, Republic of Chungnam National University Hospita Daejeon, Korea, Republic of Pusan National University Hospital Pusan, Korea, Republic of Kangbuk Samsung Hospital Seoul, Korea, Republic of Kangdong Sacred Heart Hospital Seoul, Korea, Republic of Samsung Medical Center Seoul, Korea, Republic of Seoul St. Mary's Hospital Seoul, Korea, Republic of Severance Hospital Seoul, Korea, Republic of Ajou University Hospital Suwon, Korea, Republic of Collapse << |
| NCT00600353 | Myeloma, Plasma-Cell ... more >> Lymphoma, Malignant Collapse << | Phase 2 | Completed | - | United States, Kansas ... more >> University of Kansas Medical Center Kansas City, Kansas, United States, 66160 Collapse << |
| NCT00600353 | - | - | Completed | - | - |
| NCT01370408 | - | - | Completed | - | - |
| NCT02635828 | Postoperative Nausea and Vomit... more >>ing Collapse << | Phase 4 | Completed | - | - |
| NCT02116530 | Hematopoietic/Lymphoid Cancer ... more >> Nausea and Vomiting Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 3 | Completed | - | - |
| NCT01370408 | Chemotherapy-induced Nausea an... more >>d Vomiting Collapse << | Phase 2 | Completed | - | United States, Georgia ... more >> Northside Hospital Atlanta, Georgia, United States, 30342 Collapse << |
| NCT01568268 | Laparoscopic Gynecologic, Abdo... more >>minal, Other Surgery General Anesthesia Collapse << | Phase 3 | Completed | - | Korea, Republic of ... more >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 Bungdang Seoul National University Hospital Seoul, Korea, Republic of Kangpook Samsung Hospital Seoul, Korea, Republic of Sangye Bahk Hospital, Inje School of Medicine Seoul, Korea, Republic of Collapse << |
| NCT03578081 | Malignant Neoplasm | Phase 3 | Recruiting | March 2020 | - |
| NCT00475085 | - | - | Completed | - | - |
| NCT00381862 | - | - | Completed | - | - |
| NCT00661674 | Substance-Related Disorders | Not Applicable | Completed | - | United States, California ... more >> Stanford University School of Medicine Stanford, California, United States, 94305 Collapse << |
| NCT02635828 | - | - | Completed | - | - |
| NCT02970643 | Chemotherapy-induced Nausea an... more >>d Vomiting Collapse << | Not Applicable | Unknown | December 2017 | - |
| NCT01952626 | Morphine Adverse Reaction | Not Applicable | Completed | - | Korea, Republic of ... more >> Kyungpook National Hospital Daegu, Korea, Republic of, 700-721 Collapse << |
| NCT00475085 | Nausea | Phase 3 | Completed | - | United States, Alabama ... more >> MBCCOP - Gulf Coast Mobile, Alabama, United States, 36695 United States, Illinois CCOP - Central Illinois Decatur, Illinois, United States, 62526 United States, Kansas CCOP - Wichita Wichita, Kansas, United States, 67214-3882 United States, Michigan CCOP - Grand Rapids Grand Rapids, Michigan, United States, 49503 CCOP - Kalamazoo Kalamazoo, Michigan, United States, 49007-3731 United States, Minnesota CCOP - Metro-Minnesota St. Louis Park, Minnesota, United States, 55416 United States, Missouri CCOP - Kansas City Kansas City, Missouri, United States, 64131 United States, Nevada CCOP - Nevada Cancer Research Foundation Las Vegas, Nevada, United States, 89106 United States, New York CCOP - Hematology-Oncology Associates of Central New York East Syracuse, New York, United States, 13057 CCOP - North Shore University Hospital Manhassett, New York, United States, 11030 United States, North Carolina CCOP - Southeast Cancer Control Consortium Goldsboro, North Carolina, United States, 27534-9479 United States, Ohio CCOP - Columbus Columbus, Ohio, United States, 43215 CCOP - Dayton Dayton, Ohio, United States, 45429 United States, South Carolina CCOP - Greenville Greenville, South Carolina, United States, 29615 United States, Washington CCOP - Northwest Tacoma, Washington, United States, 98405-0986 United States, Wisconsin CCOP - Marshfield Clinic Research Foundation Marshfield, Wisconsin, United States, 54449 Collapse << |
| NCT01031498 | Acute Myelogenous Leukemia ... more >> Chemotherapy-induced Nausea and Vomiting Collapse << | Phase 2 | Completed | - | United States, Texas ... more >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01031498 | - | - | Completed | - | - |
| NCT00410488 | - | - | Completed | - | - |
| NCT00661674 | - | - | Completed | - | - |
| NCT00410488 | Sarcoma Nause... more >>a Vomiting Collapse << | Not Applicable | Completed | - | United States, Texas ... more >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT00553059 | Chemotherapy-induced Nausea an... more >>d Vomiting Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 3 | Completed | - | United States, Missouri ... more >> Cancer Research for the Ozarks Springfield, Missouri, United States, 65807 United States, South Carolina CCOP - Greenville Greenville, South Carolina, United States, 29615 United States, Texas University of Texas M.D. Anderson CCOP Research Base Houston, Texas, United States, 77030-4009 United States, Vermont Vermont Cancer Center at University of Vermont Burlington, Vermont, United States, 05405 Collapse << |
| NCT01363479 | Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse << | Phase 3 | Completed | - | - |
| NCT00952133 | PONV | Phase 4 | Completed | - | United States, New York ... more >> NYU Langone Medical Center New York, New York, United States, 10016 Collapse << |
| NCT03649230 | - | - | Recruiting | March 30, 2020 | Canada, Alberta ... more >> Tom Baker Cancer Center Not yet recruiting Calgary, Alberta, Canada Canada, New Brunswick The Moncton Hospital Not yet recruiting Moncton, New Brunswick, Canada Canada, Nova Scotia NSHA-QEII Health Sciences Centre Not yet recruiting Halifax, Nova Scotia, Canada Cape Breton Cancer Centre Recruiting Sydney, Nova Scotia, Canada Canada, Ontario Royal Victoria Regional Health Centre Not yet recruiting Barrie, Ontario, Canada William Osler Health System Not yet recruiting Brampton, Ontario, Canada Grand River Regional Cancer Centre Recruiting Kitchener, Ontario, Canada London Health Sciences Centre Not yet recruiting London, Ontario, Canada Thunder Bay Regional Health Sciences Centre Not yet recruiting Thunder Bay, Ontario, Canada St. Michael's Hospital Not yet recruiting Toronto, Ontario, Canada Sunnybrook Health Sciences Center Not yet recruiting Toronto, Ontario, Canada Windsor Regional Cancer Centre Recruiting Windsor, Ontario, Canada Canada, Quebec Centre Integre de Sante et de Services Sociaux de la Monteregie-Centre Not yet recruiting Greenfield Park, Quebec, Canada Cisss de Chaudiere-Appalaches Not yet recruiting Lévis, Quebec, Canada Segal Cancer Centre-Jewish General Hospital Not yet recruiting Montréal, Quebec, Canada Centre de recherche du CHUS and Hopital Fleurimont Not yet recruiting Sherbrooke, Quebec, Canada Canada, Saskatchewan Saskatoon Cancer Centre Not yet recruiting Saskatoon, Saskatchewan, Canada Collapse << |
| NCT01363479 | - | - | Completed | - | - |
| NCT02557035 | Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse << | Phase 3 | Completed | - | - |
| NCT02557035 | - | - | Completed | - | - |
| NCT00900757 | Malignant Glioma | Phase 2 | Completed | - | United States, North Carolina ... more >> The Preston Robert Tisch Brain Tumor Center at Duke Durham, North Carolina, United States, 27710 Collapse << |
| NCT01836705 | Neoplasm Malignant | Phase 1 | Completed | - | United States, California ... more >> Investigational Site Number 840003 Los Angeles, California, United States, 90048 United States, Georgia Investigational Site Number 840007 Augusta, Georgia, United States, 30912 United States, Michigan Investigational Site Number 840002 Detroit, Michigan, United States, 48201 United States, Missouri Investigational Site Number 840001 St Louis, Missouri, United States, 63110 United States, Ohio Investigational Site Number 840004 Cincinnati, Ohio, United States, 45267-0542 United States, Pennsylvania Investigational Site Number 840005 Philadelphia, Pennsylvania, United States, 19111 United States, Texas Investigational Site Number 840006 San Antonio, Texas, United States, 78229 Investigational Site Number 840008 San Antonio, Texas, United States, 78229 Belgium Investigational Site Number 056001 Bruxelles, Belgium, 1200 Investigational Site Number 056002 Gent, Belgium, 9000 Collapse << |
| NCT01169805 | Laparoscopic Marsupialization ... more >>of Renal Cyst Collapse << | Not Applicable | Completed | - | Korea, Republic of ... more >> Severance Hospital, Yonsei University College of Medicine Seoul, Korea, Republic of, 120-752 Collapse << |
| NCT02205164 | Chemotherapy Induced Nausea an... more >>d Vomiting Collapse << | Phase 2 | Unknown | October 2014 | Italy ... more >> Università-Azienda Policlinico di Bari Active, not recruiting Bari, BA, Italy, 70124 Ospedale Perrino Recruiting Brindisi, BR, Italy, 72010 Contact: Angela Melpignano, MD brinemat@tin.it Principal Investigator: Angela Melpignano, MD Ospedale Pugliese-Ciacco Active, not recruiting Catanzaro, CZ, Italy, 88100 IRCCS Casa Sollievo della Sofferenza Recruiting San Giovanni Rotondo, FG, Italy, 71013 Contact: Nicola Cascavilla, MD nicola.cascavilla@tin.it Principal Investigator: Nicola Cascavilla, MD Ospedale Vito Fazzi Recruiting Lecce, LE, Italy, 73100 Contact: Nicola Di Renzo, MD direnzo.ematolecce@libero.it Principal Investigator: Nicola Di Renzo, MD Ospedale "Cardinale Panico" Recruiting Tricase, LE, Italy, 73100 Contact: Vincenzo Pavore, MD salentoematologia@piafondazionepanico.it Principal Investigator: Vincenzo Pavone, MD A.O. Riuniti Papardo - Piemonte Recruiting Messina, ME, Italy, 98121 Contact: Donato Mannina, MD donadani@tiscali.it Principal Investigator: Donato Mannina, MD Casa di Cura "La Maddalena" Recruiting Palermo, PA, Italy, 90127 Contact: Maurizio Musso, MD mamusso@libero.it Principal Investigator: Maurizio Musso, MD Ospedale Ascoli Civico Palermo Recruiting Palermo, PA, Italy, 90127 Contact: Anxur Merenda, MD anxurmerenda@libero.it Principal Investigator: Anxur Merenda, MD Ospedale Moscati Recruiting Taranto, TA, Italy, 74100 Contact: Patrizio Mazza, MD ematologia.taranto@libero.it Principal Investigator: Patrizio Mazza, MD ARON " Cardarelli" Recruiting Napoli, Italy, 80121 Contact: Felicetto Ferrara, MD felicettoferrara@katamail.com Principal Investigator: Felicetto Ferrara, MD Collapse << |
| NCT00967499 | Postoperative Nausea and Vomit... more >>ing Collapse << | Phase 2 | Completed | - | United States, Arizona ... more >> Precision Trials Phoenix, Arizona, United States, 85032 United States, California Accurate Clinical Trials, Inc Laguna Hills, California, United States, 92653 University of California San Francisco San Francisco, California, United States, 94115 United States, Florida University of Miami Miami, Florida, United States, 33136 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Ohio Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Texas Scott and White Hospital Temple, Texas, United States, 76508 Collapse << |
| NCT00952133 | - | - | Completed | - | - |
| NCT01650961 | Anesthesia, General ... more >> Palonosetron Collapse << | Not Applicable | Completed | - | Korea, Republic of ... more >> Seoul National University Hospital Seoul, Korea, Republic of Collapse << |
| NCT01640340 | - | - | Completed | - | - |
| NCT00343863 | Male Breast Cancer ... more >> Nausea and Vomiting Stage I Breast Cancer Stage II Breast Cancer Stage IIIA Breast Cancer Collapse << | Not Applicable | Completed | - | United States, Washington ... more >> Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 Collapse << |
| NCT00900757 | - | - | Completed | - | - |
| NCT00343863 | - | - | Completed | - | - |
| NCT00343460 | Nausea and Vomiting ... more >> Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 3 | Completed | - | - |
| NCT03367572 | Breast Carcinoma | Phase 3 | Recruiting | May 1, 2023 | United States, New York ... more >> University of Rochester NCORP Research Base Recruiting Rochester, New York, United States, 14642 Contact: Joseph Roscoe 585-275-5513 joseph_roscoe@urmc.rochester.edu Principal Investigator: Joseph Roscoe Collapse << |
| NCT01640340 | Malignant Neoplasm | Not Applicable | Completed | - | United States, Ohio ... more >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 Collapse << |
| NCT00895245 | Nausea and Vomiting ... more >> Stage III Squamous Cell Carcinoma of the Hypopharynx Stage III Squamous Cell Carcinoma of the Larynx Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity Stage III Squamous Cell Carcinoma of the Nasopharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage IV Squamous Cell Carcinoma of the Hypopharynx Stage IV Squamous Cell Carcinoma of the Larynx Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IV Squamous Cell Carcinoma of the Nasopharynx Stage IV Squamous Cell Carcinoma of the Oropharynx Collapse << | Phase 2 | Terminated(Study stopped due t... more >>o lack of efficacy in first 6 patients) Collapse << | - | United States, Washington ... more >> Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 Collapse << |
| NCT00306735 | Multiple Myeloma | Phase 2 | Completed | - | United States, Indiana ... more >> Indiana Blood and Marrow Transplantation Beech Grove, Indiana, United States, 46107 United States, New York Cornell Medical Center New York, New York, United States, 10021 United States, North Carolina Wake Forest Medical Center Winston-Salem, North Carolina, United States, 27157 United States, Oregon Oregon Health & Science University Portland, Oregon, United States, 97239 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Fox Chase-Temple Philadelphia, Pennsylvania, United States, 19111 United States, Texas Baylor University Blood and Marrow Transplantation Dallas, Texas, United States, 75246 MD Anderson Cancer Center Houston, Texas, United States, 77030 Texas Transplant Institute San Antonio, Texas, United States, 78229 United States, Virginia Fairfax-Northern Virginia Hematology-Oncology PC Fairfax, Virginia, United States, 22031 Collapse << |
| NCT00895245 | - | - | Terminated(Study stopped due t... more >>o lack of efficacy in first 6 patients) Collapse << | - | - |
| NCT00903396 | - | - | Terminated(Slow accrual) | - | - |
| NCT01481831 | Neoplasms Che... more >>motherapy-Induced Nausea and Vomiting Collapse << | Phase 4 | Completed | - | China, Anhui ... more >> Anhui Provincial Hospital Hefei, Anhui, China China, Beijing Chinese Academy of Medical Sciences Cancer Hospital Beijing, Beijing, China Chinese PLA 301 Hospital Beijing, Beijing, China Chinese PLA 307 Hospital Beijing, Beijing, China Chinese PLA Navy General Hospital Beijing, Beijing, China China, Fujian Fuzhou General Hospital of Nanjing Military Command Fuzhou, Fujian, China China, Guangxi Guangxi Cancer Hospital Nanning, Guangxi, China China, Hunan The Second Xiangya Hospital of Central South University Changsha, Hunan, China China, Jiangsu The First People's Hospital of Changzhou Changzhou, Jiangsu, China Nanjing General Hospital of Nanjing Military Command Nanjing, Jiangsu, China The First Affiliated Hospital of Soochow University Suzhou, Jiangsu, China The Fourth People's Hospital of Wuxi Wuxi, Jiangsu, China China, Shandong Shandong Cancer Hospital Jinan, Shandong, China Shandong Provincial Hospital Jinan, Shandong, China The Affiliated Hospital of Medical College Qingdao University Qingdao, Shandong, China China, Shanghai Shanghai Changzheng Hospital Shanghai, Shanghai, China Shanghai Xinhua Hospital Shanghai, Shanghai, China China, Shanxi Tangdu Hospital of Fourth Military Medical University Xian, Shanxi, China Collapse << |
| NCT03097588 | Hematopoietic Cell Transplanta... more >>tion Recipient Malignant Neoplasm Collapse << | Phase 2 | Recruiting | May 2019 | United States, Oregon ... more >> OHSU Knight Cancer Institute Recruiting Portland, Oregon, United States, 97239 Contact: Joseph Bubalo 503-494-8007 bubaloj@ohsu.edu Principal Investigator: Joseph Bubalo Collapse << |
| NCT00343460 | - | - | Completed | - | - |
| NCT00903396 | Anal Cancer C... more >>arcinoma of the Appendix Colorectal Cancer Extrahepatic Bile Duct Cancer Gallbladder Cancer Gastric Cancer Gastrointestinal Carcinoid Tumor Liver Cancer Nausea and Vomiting Pancreatic Cancer Primary Peritoneal Cavity Cancer Small Intestine Cancer Collapse << | Phase 2 | Terminated(Slow accrual) | - | - |
| NCT03148704 | - | - | Recruiting | June 8, 2018 | China, Jiangsu ... more >> The 81st Hostital of PLA Recruiting Nanjing, Jiangsu, China, 210000 Contact: qin shukui Collapse << |
| NCT00636805 | - | - | Terminated(Study was halted ea... more >>rly after 63 subjects were enrolled due to slow accrual.) Collapse << | - | - |
| NCT00636805 | Brain Cancer | Phase 2 | Terminated(Study was halted ea... more >>rly after 63 subjects were enrolled due to slow accrual.) Collapse << | - | United States, North Carolina ... more >> Duke University Medical Center Durham, North Carolina, United States, 27710 Collapse << |
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